Effect of Adipose Tissue-derived Stem Cells on Periorbital Wrinkles

Abstract

Objective: To evaluate the effect of adipose tissue-derived stem cells in the treatment of periorbital wrinkles.

Methods: Randomized double-blind comparative trial in the Plastic Surgery Service of the Clinical Surgical Hospital "Hermanos Ameijeiras" in the period since September/2019 until July/2021. The sample consisted of 70 patients who met the selection criteria and were distributed into two treatment groups.

Results: Women predominated (88.6%) with an average age of 47 years with no significant differences between the treatment groups. The 60.0% of the study group and 62.9 % of the control group presented skin phototype II with no significant differences between the groups (p = 0.855). The highest percentage of aging corresponded to III and the lowest to IV (14.3% vs. 20.0%), with no significant differences between the groups (p = 0.487). Before treatment, there was a higher frequency of moderate (study: 42.9%; control: 51.4%) and severe wrinkles (study: 42.9%; control: 34.3%). After the intervention, there was a superior improvement in the study group with significant changes in both treated groups (p < 0.001). There was one complication in the control group (2.9%). 100% were satisfied and the results were good in the study group (94.3%) and regular in equal proportion of the control with significant differences (p < 0.001).

Conclusions: Stem cell-assisted lipotransfer offers superior results to conventional lipotransfer in periorbital rejuvenation.