Corneal biopsy: clinical and histopathological correlation
Keywords:
keratoplasty; corneal biopsy; histological.Abstract
The objective of the article was to expose clinical and diagnostic aspects, through presumptive images, of the most frequent conditions of the ocular half-transparent cornea with prolate curved structure and maximum optical power, and in this way, expand the information on histopathological confirmation. Clinical and histological correlation of corneal biopsies from surgical procedures was carried out in 708 of the most frequent conditions treated in Cuba. It was proven that there is a high correspondence between the clinical and histological diagnosis, which makes it possible to explain and improve knowledge in relation to diagnostic visual acuity, particularly in the face of corneas that have lost their transparency or become opaque. Special staining and immunohistochemical techniques were applied.
Downloads
References
1. Yanoff M, Sassani JW. Cornea and Sclera. Ocular pathology. 8 ed. St Louis: Elsevier; 2019. p. 272-356.
2. Mokey Castellanos MO. Indicaciones de la queratoplastia en un centro de referencia nacional. Revista Cubana de Oftalmología. 2000 [acceso 12/05/2021];13(1). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-21762000000100006&lng=es
3. Pérez-Suárez RG, MoKey Castellanos MO, Hernández-Hurtado AS, Casas-Arias X, Álvarez-Rivero MB. Cambios topoaberrométricos posqueratoplastia lamelar anterior superficial asistida con láser excimer en el queratocono grado III. 2012;86(3):164-70.
4. Alio JL, Montesel A, El Sayyad F, Barraquer RI, Arnalich-Montiel F, Alio Del Barrio JL. Corneal graft failure: an update. Br J Ophthalmol. 2021;105(8):1049-58. DOI: 10.1136/bjophthalmol-2020-316705
5. Barraquer RI, Pareja-Arico L, Gomez-Benlloch A, Michael R. Risk factors for graft failure after penetrating keratoplasty. Medicine (Baltimore). 2019;98(17):e15274. DOI: 10.1097/MD.0000000000015274
6. Sel S, Stange J, Kaiser D, Kiraly L. Repeatability and agreement of Scheimpflug-based and swept-source optical biometry measurements. Cont Lens Anterior Eye. 2017;40(5):318-22. DOI: 10.1016/j.clae.2017.03.007
7. Barraquer R, Alvarez de Toledo J, Alfonso J, Celis J, Etxebarria J, Güell J. Técnicas de diagnóstico por la imagen en queratoplastia. Queratoplastias: Nuevas técnicas para el siglo XXI. Madrid: Sociedad Española de Oftalmología; 2016. p. 51-8.
8. Mannis MJ, Holland EJ. Specular Microscopy. Cornea: Fundamentals, Diagnosis and Management. 5 ed. Toronto: Elsevier; 2022. p. 160-79.
9. Scarpa F, Ruggeri A (editors). Automated morphometric description of human corneal endothelium from in-vivo specular and confocal microscopy. 38th Annu Int Conf IEEE. Eng Med Biol Soc. 2016:1296-99. DOI: https://doi.org/10.1109/EMBC.2016.7590944
10. Huang J, Maram J, Tepelus TC, Sadda SR, Chopra V, Lee OL. Comparison of Noncontact Specular and Confocal Microscopy for Evaluation of Corneal Endothelium. Eye Contact Lens. 2018;44(Suppl 1):S144-S50. DOI: 10.1097/ICL.0000000000000362
11. Feizi S. Corneal endothelial cell dysfunction: etiologies and management. Ther Adv Ophthalmol. 2018;10:2515841418815802. DOI: 10.1177/2515841418815802
12. Yang T, Castellanos MOM, Rivero MBÁ. Therapeutic update on pseudophakic bullous keratopathy. Revista Cubana de Oftalmología. 2020;33(1):1-13. Disponible en: https://www.medigraphic.com/pdfs/revcuboft/rco-2020/rco201l.pdf
13. Pricopie S, Istrate S, Voinea L, Leasu C, Paun V, Radu C. Pseudophakic bullous keratopathy. Rom J Ophthalmol. 2017;61(2):90-4. DOI: 10.22336/rjo.2017.17
14. Abud TB, Di Zazzo A, Kheirkhah A, Dana R. Systemic Immunomodulatory Strategies in High-risk Corneal Transplantation. J Ophthalmic Vis Res. 2017;12(1):81-92. DOI: 10.4103/2008-322X.200156
15. Siu GD, Young AL, Jhanji V. Alternatives to corneal transplantation for the management of bullous keratopathy. Curr Opin Ophthalmol. 2014;25(4):347-52. DOI: 10.1097/ICU.0000000000000062
16. Ang M, Baskaran M, Werkmeister RM, Chua J, Schmidl D, Aranha Dos Santos V, et al. Anterior segment optical coherence tomography. Prog Retin Eye Res. 2018;66:132-56. DOI: 10.1016/j.preteyeres.2018.04.002
17. Mokey Castellanos MO, Álvarez Rivero MB. Queratoplastia penetrante con y sin terapia antiviral en la queratopatía herpética. Revista Cubana de Oftalmología. 2020 [acceso 12/05/2021];33(1). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-21762020000100002
18. Sarhan AE-RE, Elhagaa AA, Shakal FA. The role of preoperative Pentacam in optimizing visual outcome after cataract surgery. Menoufia Med J. 2020 [acceso 12/05/2021];33(2):546. Disponible en: http://www.mmj.eg.net/text.asp?2020/33/2/546/287803
19. Chourasia P, Mehta A. Effect of Surgically Induced Astigmatism on Sutured and Sutureless Incisions Placed at Various Superior Locations after Phacoemulsification Cataract Surgery Performed for Age Related Cataracts. Int J Res Review. 2019 [acceso 12/05/2021];6(10):146-62. Disponible en: https://www.ijrrjournal.com/IJRR_Vol.6_Issue.10_Oct2019/IJRR0022.pdf
20. Verdiguel-Sotelo K, Carrasco-Quiroz A, Rangel-Servín J. Categoría pronóstica de trasplante corneal en un centro de referencia. Rev Med Inst Mex Seguro Soc. 2017 [acceso 12/05/2021];54(6):738-45. Disponible en: https://www.medigraphic.com/pdfs/imss/im-2016/im166h.pdf
21. Rodiles Martinez HC, Campanón Logaz JE, Laza Caballero C. Citohistopatología. Procedimientos básicos. La Habana: ECIMED; 2008.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Revista Cubana de Oftalmología
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
El contenido de la revista se encuentra accesible sin costo alguno. Está protegido por los términos de la Licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional
