Artifacts of Optical Coherence Tomography Angiography in Glaucoma
Keywords:
glaucoma, artifacts, optical coherence tomography angiography, signal intensityAbstract
Artifacts are a common limitation of all imaging devices, especially for new technologies such as optical coherence tomography angiography. The objective of this research is to identify the frequency, type, risk factors, clinical impact, and current methods for the correction of optical coherence tomography angiography artifacts in glaucoma. A systematic search of the highest-impact scientific literature was performed. It was limited by type of design (reviews, case series, descriptive, analytical and experimental studies, meta-analysis). The language of publication was not taken into account. Artifacts are present in 72-100 % of cases. They vary according to the type of artifact and optical coherence tomography angiography device studied. Poor image quality and underlying posterior segment disease are associated with their higher prevalence. The most frequent are motion and projection artifacts. Optical coherence tomography angiography images frequently present artifacts. Identifying and interpreting their presence improves the clinical care of patients.
Downloads
References
1. Tanna AP, Boland MV, Giaconi JA, Krishnan C, Lin SC, Medeiros FA, et al (ed.). Introduction to Glaucoma: Terminology, Epidemiology and Genetics. En: American Academy of Ophthalmology. Basic and Clinical Science Course 2022-2023. San Francisco: American Academy of Ophthalmology; 2022 [acceso 22/02/2024]. Disponible en: https://books.google.com.cu/books/about/2021_2022_Basic_and_Clinical_Science_Cou.html?id=ASagzgEACAAJ&redir_esc=y
2. Rao HL, Pradhan ZS, Suh MH, Moghimi S, Mansouri K, Weinreb RN. Optical Coherence Tomography Angiography in Glaucoma. Journal of glaucoma. 2020;29(4):312-21. DOI: 10.1097/IJG.0000000000001463
3. Anvari P, Ashrafkhorasani M, Habibi A, Falavarjani KG. Artifacts in Optical Coherence Tomography Angiography. J Ophthalmic Vis Res. 2021;16(2):271-86. DOI: 10.18502/jovr.v16i2.9091
4. Kooner K RM, Suresh S, Buchanan E, Albdour M, Zuberi H. The Role of Optical Coherence Tomography Angiography in Glaucoma. Optical Coherence Tomography-Developments and Innovations in Ophthalmology.IntechOpen. 2023. DOI: 10.5772/intechopen.110272
5. Bontzos G, Kabanarou SA, Garnavou-Xirou C, Gkizis I, Kontou E, Triantafyllou D, et al. Segmentation errors and motion artifacts in OCT-A associated with epiretinal membranes. Can J Ophthalmol. 2020;55(4):293-300. DOI: 10.1016/j.jcjo.2019.12.007
6. Kleerekooper I, Houston S, Dubis AM, Trip SA, Petzold A. Optical Coherence Tomography Angiography (OCTA) in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder. Front Neurol. 2020;11:604049. DOI: 10.3389/fneur.2020.604049
7. Bayer A, Akman A. Artifacts and Anatomic Variations in Optical Coherence Tomography. Turkish journal of ophthalmology. 2020;50(2):99-106. DOI: 10.4274/tjo.galenos.2019.78000
8. Kamalipour A, Moghimi S, Hou H, Penteado RC, Oh WH, Proudfoot JA, et al. OCT Angiography Artifacts in Glaucoma. Ophthalmology. 2021;128(10):1426-37. DOI: 10.1016/j.ophtha.2021.03.036
9. Abu-Yaghi NE, Obiedat AF, AlNawaiseh TI, Hamad AM, Bani Ata BA, Quzli AA, et al. Optical Coherence Tomography Angiography in Healthy Adult Subjects: Normative Values, Frequency, and Impact of Artifacts. Biomed Res Int. 2022;2022:7286252. DOI: 10.1155/2022/7286252
10. Ashraf M, Sampani K, Abu-Qamar O, Cavallerano J, Silva PS, Aiello LP, et al. Optical Coherence Tomography Angiography Projection Artifact Removal: Impact on Capillary Density and Interaction with Diabetic Retinopathy Severity. Translational Vision Science & Technology. 2020;9(7):10-17. DOI: 10.1167/tvst.9.7.10
11. Stepien KE, Konda SM, Etheridge T, Holmen I, Kopplin L, Pak JW, et al. Impact of artifacts in optical coherence tomography angiography image analysis. Investigative Ophthalmology & Visual Science. 2020 [acceso 15/03/2024];61(7):4818-26. Disponible en: https://iovs.arvojournals.org/article.aspx?articleid=2768707
12. Li A, Thompson AC, Asrani S. Impact of Artifacts From Optical Coherence Tomography Retinal Nerve Fiber Layer and Macula Scans on Detection of Glaucoma Progression. Am J Ophthalmol. 2021;221:235-45. DOI: 10.1016/j.ajo.2020.08.018
13. Gómez-Ulla F R-MJ, Arias L. Artefactos en la OCTA y calidad de la imagen obtenida. En: Angiografía por Tomografía de Coherencia Óptica (OCTA) 97 PonenciaOficial de la Sociedad Española de Oftalmología. España. 2021 [acceso 15/03/2024]. Disponible en: https://www.oftalmoseo.com/libros_seo/ponencia_seo/angiografia-por-tomografia-de-coherencia-optica-octa-2/
14. Holmen IC, Konda SM, Pak JW, McDaniel KW, Blodi B, Stepien KE, et al. Prevalence and severity of artifacts in optical coherence tomographic angiograms. JAMA ophthalmology. 2020;138(2):119-26. DOI: 10.1001/jamaophthalmol.2019.4971
15. Iftikhar M, Zafar S, Gonzalez N, Murphy O, OhemaaKwakyi MS, Sydney Feldman BS, et al. Image Artifacts in Optical Coherence Tomography Angiography Among Patients with Multiple Sclerosis. Curr Eye Res. 2019;44(5):558-63. DOI:10.1080/02713683.2019.1565892
16. Poon LY, Wang CH, Lin PW, Wu PC. The prevalence of optical coherence tomography artifacts in high myopia and its influence on glaucoma diagnosis. J Glaucoma.2023;32(9):725-33. DOI: 10.1080/02713683.2019.1565892
17. Weijing C, Zhang X, Wang W. Artifacts associated with swept-source OCT-angiography measurements in glaucoma. Investigative Ophthalmology & Visual Science. 2020 [acceso 10/03/2024];61(7):4117-26. Disponible en: https://iovs.arvojournals.org/article.aspx?articleid=2769383
18. Cheng W, Song Y, Lin F, Xiong J, Li F, Jin L, et al. Assessment of Artifacts in Swept-Source Optical Coherence Tomography Angiography for Glaucomatous and Normal Eyes. Translational Vision Science & Technology. 2022;11(1):23. DOI: 10.1167
19. Enders C, Lang GE, Dreyhaupt J, Loidl M, Lang GK, Werner JU. Quantity and quality of image artifacts in optical coherence tomography angiography. PloS One. 2019;14(1):e0210505. DOI: 10.1371/journal.pone.0210505
20. Ghasemi Falavarjani K, Habibi A, Anvari P, Ghasemizadeh S, Ashraf Khorasani M, Shenazandi H, et al. Effect of segmentation error correction on optical coherence tomography angiography measurements in healthy subjects and diabetic macular edema. Br J Ophthalmol. 2020;104(2):162-6. DOI: 10.1136/bjophthalmol-2019-314018
21. Eastline M, Munk MR, Wolf S, Schaal KB, Ebneter A, Tian M, et al. Repeatability of Wide-field Optical Coherence Tomography Angiography in Normal Retina. Transl Vis Sci Technol. 2019;8(3):6. DOI: 10.1167/tvst.8.3.6
22. PKP M, Patel M, Kim-Cavdar KKS, Editors. OCT-A artifacts in healthy, ocular hypertension, glaucoma suspect, myopic and glaucomatous eyes. In: American Academy of Ophthalmology annual Meeting. Chicago IL. 2022 [acceso 15/03/2024]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184968
23. Hood DC, La Bruna S, Tsamis E, Thakoor KA, Rai A, Leshno A, et al. Detecting glaucoma with only OCT: Implications for the clinic, research, screening, and AI development. ProgRetin Eye Res. 2022;90:101052. DOI: 10.1016/j.preteyeres.2022.101052
24. Lauermann JL, Woetzel AK, Treder M, Alnawaiseh M, Clemens CR, Eter N, et al. Prevalences of segmentation errors and motion artifacts in OCT-angiography differ among retinal diseases. Graefe's Arch ClinExpOphthalmol. 2018;256(10):1807-16. DOI: 10.1007/s00417-018-4053-2
25. Hormel TT, Huang D, Jia Y. Artifacts and artifact removal in optical coherence tomographic angiography. Quant Imaging Med Surg. 2020;11(3):1120-33. DOI: 10.21037/qims-20-730
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Revista Cubana de Oftalmología
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
El contenido de la revista se encuentra accesible sin costo alguno. Está protegido por los términos de la Licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional
