Changes in the Corneal Endothelium in Patients after Phacoemulsification Trabeculectomy
Keywords:
cataract; corneal endothelium; phaco-trabeculectomy; glaucomaAbstract
Objective: To describe corneal endothelium changes in patients who underwent phacoemulsification trabeculectomy.
Methods: A descriptive, prospective, longitudinal study was conducted in patients who underwent phacoemulsification trabeculectomy at the Ramón Pando Ferrer Cuban Institute of Ophthalmology between January 2018 and December 2020. The sample consisted of 82 eyes from 42 patients. Statistical analysis was performed using the arithmetic mean, standard deviation, percentage, and absolute frequency.
Results: The average age was 72.4 years, and females and non-white skin color predominated. Cell density decreased one month and one year after surgery. The coefficient of variability decreased with statistical significance between each interval. Hexagonality decreased one month and one year after surgery. Age greater than or equal to 70 years and preoperative intraocular pressure values greater than or equal to 20 mmHg influenced the loss of corneal endothelial cells.
Conclusions: Phacotrabeculectomy causes changes in endothelial cell density, coefficient of variation, and hexagonality, which appear to be related to general risk factors such as advanced age and elevated intraocular pressure. However, factors associated with the surgical technique must also be considered.
Downloads
References
1. Allison K, Patel D, Alabi O. Epidemiology of glaucoma: the past, present, and predictions for the future. Cureus. 2020;12(11):e11686. DOI: https://doi.org/10.7759/cureus.11686
2. Sánchez Acosta L, Obret Mendive I, Cárdenas Chacón D, Campos Bacheretea N, Chaviano León G. Efectividad y seguridad de la facotrabeculectomía por dos vías. Rev Cubana Oftalmol. 2023 [acceso 11/07/2025];36(2). Disponible en: https://revoftalmologia.sld.cu/index.php/oftalmologia/article/view/1761
3. Mangan MS, İmamoglu S. Uneventful Phacoemulsification after Trabeculectomy in Pseudoexfoliation Glaucoma versus Primary Open-Angle Glaucoma. Ophthalmic Res. 2023;66(1):672-80. DOI: https://doi.org/10.1159/000529642
4. Soro Martínez MI, Miralles de Imperial-Ollero JA, Pastor Montoro M, Arcos Villegas G, Sobrado Calvo P, Ruiz Gómez JM, et al. Corneal endothelial cell loss after trabeculectomy and phacoemulsification in one or two steps: a prospective study. Eye. 2021 [acceso 12/08/2023];35:2999-3006. DOI: https://doi.org/10.1038/s41433-020-01331-x
5. Declaración de Helsinki de la AMM – Principios éticos para las investigaciones médicas en seres humanos-OPS/OMS | Organización Panamericana de la Salud; 2024 [acceso 12/07/2025]. Disponible en: https://www.paho.org/es/documentos/declaracion-helsinki-amm-principios-eticos-para-investigaciones-medicas-seres-humanosPaho.org
6. Kaliardas A, Chatziralli I, Katsanos A, Kitsos G. Phacoemulsification versus Phacoemulsification/Trabeculectomy for the Treatment of Primary Open-Angle Glaucoma Coexistent with Cataract: A Comparative Study. Medicina (Kaunas). 2023;59(3):470. DOI: https://doi.org/10.3390/medicina59030470
7. Hamid S, Desai P, Hysi P, Burr JM, Khawaja AP. Population screening for glaucoma in UK: current recommendations and future directions. Eye. 2021;36(3):504. DOI: https://doi.org/10.1038/s41433-021-01687-8
8. Fumero González FY, Fernández Argones L, Pérez Rangel Y, Herrera Padrón M. Complicaciones posoperatorias de la facoemulsificación asociada a trabeculectomía gonioasistida modificada con tijeras. Rev Cubana Oftalmol. 2023 [acceso 12/07/2024];36(1):e1737. Disponible en: http://www.revoftalmologia.sld.cu/index.php/oftalmologia/article/view/1737&ved
9. Gillman K, Bravetti GE, Rao HL, Mermoud A, Mansouri K. Impact of phacoemulsification combined with XEN gel stent implantation on corneal endotelial cell density: 2-year results. J Glaucoma. 2020;29(3):155-60. DOI: https://doi.org/10.1097/IJG0000000000001430
10. Soro-Martínez MI, Miralles de Imperial-Ollero JA, Pastor-Montoro M, Arcos-Villegas G, Sobrado-Calvo P, Ruiz-Gómez JM, et al. Corneal endothelial cell loss after trabeculectomy and phacoemulsification in one or two steps: a prospective study. Eye (Lond). 2021 Nov;35(11):2999-3006. DOI: https://doi.org/10.1038/s41433-020-01331-x
11. Lundberg B. Corneal endothelial changes seven years after phacoemulsification cataract surgery. Int Ophthalmol. 2024;44(1):169. DOI: https://doi.org/10.1007/s10792-024-03044-6
12. Yang W, Zhao J, Sun L, Zhao J, Niu L, Wang X, et al. Four year observation of the changes in corneal endothelium cell density and correlated factors after implantable collamer lens V4c implantation. Br J Ophtalmol. 2021;105:625-30. DOI: https://doi.org/10.1136/bjophthalmol-2021-319374
13. Abd El-Aziz Mohamed Salah M, El-Sayed El-Baz, Mostafa El-Sayed S. Corneal endotelial cell change after trabeculectomy with mitomycin-C in glaucoma patients. Al-Azhar Med J. 2021;50(4):2473-84. DOI: https://doi.org/10.21608/amj.2021.196388
14. Ciorba AL, Roiu G, Abdelhamid AM, Saber S, Cavalu S. Evaluation of the corneal endothelium following cataract surgery in diabetic and non-diabetic patients. Diagnostics. 2023;13(6):1115. DOI: https://doi.org/10.3390/diagnostics13061115
15. Sorrentino FS. Qualitative alterations on corneal endothelial cell morphometry and hexagonality after cataract surgery. Clin Ophthalmol. 2021;15:4847-53. DOI: https://doi.org/10.2147/OPTH.S338001
16. Lundberg B. Corneal endothelial changes seven years after phacoemulsification cataract surgery. Int Ophthalmol. 2024 Apr 8;44(1):169. DOI: https://doi.org/10.1007/s10792-024-03044-6
17. Vaiciuliene R, Rylskyte N, Baguzyte G, Jasinskas V. Risk factors for corneal endothelial cell density: a review. Exp Ther Med. 2022;23:129. DOI: https://doi.org/10.3892/etm.2021.11052
18. Hu J, Zhao C, Luo Y, Kong J, Shi W, Wang T. Real-time corneal thickness changes during phacoemulsification cataract surgery. Graefes Arch Clin Exp Ophthalmol. 2023;261(6):1609-18 DOI: https://doi.org/10.1007/s00417-022-05971-5
19. Andini EA, Avianty A, Herman H, Choliq A. Efficacy and Safety of Manual Small-Incision Cataract Surgery with Trabeculectomy Versus Phacotrabeculectomy in Patients with Glaucoma and Cataract: A Systematic Review and Meta-Analysis. Cureus. 2023;15(12):e51025. DOI: https://doi.org/10.7759/cureus.51025
20. Cho SW, Kim JM, Choi CY, Park KH. Changes in corneal endotelial cell density in patients with normal-tension glaucoma. Jap J Ophtalmol. 2009;53(6):659-73. DOI: https://doi.org/10.1007/s10384-009-0740-1
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Revista Cubana de Oftalmología

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
El contenido de la revista se encuentra accesible sin costo alguno. Está protegido por los términos de la Licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional