Clinical and Epidemiological Features of Conjunctival Intraepithelial Neoplasia

Abstract

Objective: To determine the clinical-epidemiologic characteristics and clinical-anatomopathological correlation of conjunctival intraepithelial neoplasia.

Methods: An observational, descriptive and retrospective, explanatory, cohort study of patients over 18 years of age, attended at the Cuban Institute of Ophthalmology Ramón Pando Ferrer in the period from January 2017 to December 2019 with initial diagnosis of intraepithelial neoplasia of the conjunctiva, who underwent surgery, a sample was taken for biopsy and the clinical-anatomopathological correlation was studied. Variables analyzed were age, sex, skin color, tumor location, clinical characteristics, risk factors and anatomopathological studies performed.

Results: 604 patients were studied, with a mean age of 50 years (±14,6 years), female sex and skin color bank were the most frequent (60,8 % and 62,6 %, respectively), the predominant location was the bulbar interpalpebral conjunctiva (59,9 %) and there was concordance between impression cytology and biopsy in 66 % of patients and in preoperative clinical diagnosis and biopsy in 79,3 %.

Conclusions: The concordance between preoperative clinical diagnosis, impression cytology and postsurgical anatomopathological diagnosis was good for all major conjunctival intraepithelial neoplasms for grade II. However, the Kappa index presented a weak match.

Keywords: ocular surface tumors; conjunctival intraepithelial neoplasia; ocular surface squamous neoplasia.